Peptidyl-Dipeptidase A

A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020).

Also Known As:

Angiotensin Converting Enzyme; Angiotensin I-Converting Enzyme; Carboxycathepsin; Dipeptidyl Peptidase A; Kininase A; ACE1 Angiotensin Converting Enzyme 1; Angiotensin I Converting Enzyme; Carboxypeptidase I, Dipeptidyl; Peptidyl Dipeptidase A; ACE1 Angiotensin-Converting Enzyme 1; ACE1 Protein; Angiotensin Converting Enzyme 1; Antigens, CD143; CD143 Antigens; Dipeptidyl Carboxypeptidase I; Kininase II; Peptidase P

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Exopeptidases: 70
        Dipeptidyl-Peptidases and Tripeptidyl-Peptidases: 392
        Peptidyl-Dipeptidase A: 10436

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Disease

Drug/Important Bio-Agent (IBA)